Someone should do a zipfian analysis of a dictionary, and see what ratio of words are only used once; in their own definitions. If they are never used again, one can safely eliminate them from the language, as they won't affect the rest.
Of all the homonyms, the affect/effect one is the most cruel. To say them both uh-ffect, with the schwa in front, is a horrible, horrible way to let your sensibilities die. Aaa-ffect and eee-ffect are the only way this is ever going to work.